Session 18: Placental Tech - Q&A
Questions for Dr. Matthew Kemp:
- Do you think we will ever be able to completely circumvent the uterus and transfer embryos straight into an artificial device?
- Cassie Roeca: I believe you mentioned that EVE would ideally support human babies for 3-4 weeks to get out of the extremely-premature range. However, babies beyond 28 and 30 weeks also face severe morbidity risk. Is there the thinking that EVE treated babies would be “healthier” 30wk premies than naturally born 30 wk premies?
- Answered live
- Dr. Matthew Kemp: good question! agreed - term is best - i think we are talking about relative risk - 28-30 weeks being much better than 24. At the current stage of development 4 weeks seems more likely than 16+ weeks - but that may change as the technology develops
- Can you supplement lung surfactant?
- Dr. Vikash Verma: As always, the aim is very prudent here i.e. with a focus to protect extremely Preterm babies. What are Dr. Matthew's concerns on how could such a power technology be exploited irresponsibly (whenever ready in future) and what steps scientists are taking, proactively, to avoid such exploitative scenarios.
- Answered live
- Dr. Matthew Kemp: I am not too concerned about misuse - for a couple of reasons. Firstly, the tech is fairly costly to manage and requires a fairly large cross-functional team - so this is not something that could be setup privately very easily - really only in a public health system.
Secondly, the technology is reliant on being able to catheterise vessels and have a heart that is strong enough to drive the system. Our view is that the hard floor here is really around 20 or 21 weeks of gestation.
- Cassie Roeca: To what human gestational age would the EVE therapy translate? < 22 wks?
- jorge Ramirez: Do you use corticoids or something else to mature the lungs?
- Anabella Marconetto: Does the EVE allows to take blood samples of the baby?
- Dr. Matthew Kemp: hello - yes we sample about 4hourly
- Is overall growth of the lamb the same or delayed?
- diego ezcurra: Considering the global picture you showed of 1,5M and an average number of weeks of preterm birth, for how many weeks you should keep the human babies in an artificial placenta to get to the lower number of mortality you proposed?
- Kamolideen Akintoye: How did they know the required nutrients and the proportion required at that stage
- Dr. Matthew Kemp: our neonatal team estimates nutritional requirements based on those from clinical use at a relevant GA and then converted to sheep. So something of an informed guess.
Questions for Mats Brännström
- Turabi Yilmaz: Thank you for your good presentation, I am curious that donor ovaries are also included in the uterus transplantation?..probably asking CAN ovaries also be transplanted with the uterus.
- Robotic surgery makes the donor part quicker? More precise or more comfortable for the many physicians involved?
- Liesl Nel-Themaat: Do you have to remove the transplanted uterus after a baby is delivered, or can it remain in the women to use for a subsequent pregnancy?
- Dara Berger: Do you have frozen embryo requirements before someone is allowed to have a uterus transplant?
- Peter Nagy - in most countries GC is not allowed by law (like Sweden, so UTx makes sense). However, In some, like the US, GC is permitted. GC costs less, and possibly carries less risk to carry out a pregnancy. So, what are the advantages to perform UTx in countries where GC is permitted?
- Usama Mohamed Mostafa: Why hysterectomy after cs?