Session 21 - PGTA: Q&A Triage

Questions for Dr. Gary Harton

With the results and by comparison with the reference data the following table will be calculated

False Positive (FP)

# false pos./total

False Negative (FN)

# false neg./total

No Call Rate

# no result/# samples

Sensitivity (per embryo/cell, TN)

# true pos./(true pos. + false neg.)

Sensitivity (per chromosome)

# true pos./(true pos. + false neg.)

Specificity (per embryo/cell, TN)

# true neg./(true neg. + false pos.)

Specificity (per chromosome)

# true neg./(true neg. + false pos.)

 

Evaluation criteria will be based on the Percentage of Agreement (PA) between results obtained at the customer site and results provided for the samples included in the kit.

PA (%) = 100 x [TP +TN/ (TP+TN+FP+ FN)]

Questions for Dr. Peter Nagy

SART 2018

PGT-A was performed

< 35

35 - 37

38 - 40

41 - 42

> 42

Number of cycle starts

6938

5116

3954

1573

912

Clinical pregnancies

60%

60%

59%

57%

56%

Miscarriage rate

15%

13%

13.5%

13.5%

14.5%

Implantation rate

53%

55%

53.7%

52.4%

51.0%

PGT-A was NOT performed

< 35

35 - 37

38 - 40

41 - 42

> 42

Number of cycle starts

19332

10658

6821

2419

1903

Clinical pregnancies

56%

52%

46%

37%

27%

Miscarriage rate

17%

19%

23.0%

31.2%

37.9%

Implantation rate

46%

41%

33.1%

22.9%

14.9%

Questions for Dr. David McCulloh

Questions for Dr. Dawn Kelk

        General Questions