Session 69: The Embryo in Culture: Imprinting, Oxidative Stress and Epigenetic Homeostasis
Tuesday 22nd June, 2021. 3PM EST/ 8PM GMT / 9PM CET
Sponsored by Cook Medical
DR. KAY ELDERFollowing an academic career that included degrees in biochemistry (BSc, University of St Andrews), molecular biology (PhD, University of Colorado Medical School) and medicine (MBBChir, Cambridge), Kay Elder joined the Bourn Hall team as Clinical Assistant to Patrick Steptoe in 1984, directing the Out-Patient Department from 1985-1987 before joining the IVF lab as Senior Embryologist. Prior to medical studies in Cambridge, she was a research scientist at Imperial Cancer Research Fund in London. In 1989 she initiated and directed a program of Continuing Education for IVF doctors, scientists and nurses for the next 16 years, during which time she helped to set up and run two Master’s degree programs in Clinical Embryology. Kay was appointed Deputy Editor to Bob Edwards for the journal RBMonline from 2005. She has published 8 textbooks for IVF students and continues to mentor and tutor postgraduate students.
In her current role as Senior Research Scientist at Bourn Hall, she co-ordinates research collaborations with academic research establishments and provides information and counselling for patients who wish to donate gametes or embryos to research.
PROFESSOR YVES MENEZO
Epigenetic homeostasis and human embryo culture
Kay Elder International IVF Initiative, June 22nd 2021
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Ménézo Y, Clement P, Clement A, Elder K (2020). Methylation: an ineluctable biochemical and physiological process essential to the transmission of life (Review). International Journal of Molecular Sciences 21, 9311 https://doi.org/10.3390/ijms21239311.
Ménézo Y, Clement P, Dale B, Elder K (2021) Modulating oxidative stress and epigenetic homeostasis in preimplantation IVF embryos. Zygote, in press.
Ménézo Y, Clement P, Dale B (2019) DNA methylation patterns in the early human embryo and the epigenetic/imprinting problems: a plea for a more careful approach to human Assisted Reproductive Technology (ART). Int J Mol Sci 20(6):1342. https://doi.org/10.3390/ijms20061342.
Ménézo Y, Dale B, Elder K (2017). Time to re-evaluate ART protocols in the light of advances in knowledge about methylation and epigenetics: An Opinion paper.
Human Fertility 21(3): 1-7.
Ménézo Y, Elder K (2020) Epigenetic remodelling of chromatin in human ART: addressing deficiencies in culture media (Review) JARG 37: 1781-1788.
Ménézo Y, Elder K, Benkhalifa M, Dale B (2010) DNA methylation and gene expression in IVF. RBM Online 20 (6): 709-710.
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Ménézo Y, Lichtblau I, Elder K (2013) New insights into human pre-implantation metabolism in vivo and in vitro. JARG 30(3):293-303.
Ménézo Y, Elder K, Dale B (2019) The negative impact of the environment on methylation/epigenetic marking in gametes and embryos: A plea for action
to protect the fertility of future generations. Molecular Reproduction and Development 86(10):1273–1282.
Ménézo Y, Elder K, Dale B (2015). A link between increased prevalence of ASD syndromes and oxidative stress, DNA methylation and imprinting: the impact of the environment. JAMA Pediatrics 169(11). DOI 10.1001/jamapediatrics.2015.2125.
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