Sperm Genomic Integrity
Dr. Alessandra Parrella
Alessandra Parrella is a reproductive scientist and clinical embryologist at the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine holding an academic faculty position at Weill Cornell Medicine in New York. Alessandra has developed and implemented new clinical treatment in male factor infertility. One such project aims at assessing sperm chromatin fragmentation (SCF) from different levels of the male genital tract leading to the utilization of surgically retrieved spermatozoa in these men. In men with high DNA fragmentation,
Alessandra has been successful in achieving high clinical pregnancy rate by selecting spermatozoa through a microfluidic device yielding the highest portion of progressively motile cells characterized by the highest genomic integrity. Using the Next Generation Sequencing, she is currently assessing the gene expression profile of spermatozoal RNA and Proteomics in men with idiopathic infertility. Alessandra is dedicating her carrier to introducing new bioassays and to devise new treatment strategies to alleviate male infertility.